Associated Papers
Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2.
Chakraborty A et al.
Frontiers in Molecular Biosciences, 2022
Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein.
Toyama Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H et al.
Iubmb Life, 2020
Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells.
Hur W et al.
Cells, 2019
Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2.
Wagh AR et al.
Bioscience Reports, 2018
Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2.
Merski M et al.
Cell Death & Disease, 2017
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.
Fitzgerald JC et al.
Brain : a Journal of Neurology, 2017
Structural insights into the activation mechanisms of human HtrA serine proteases.
Zurawa-Janicka D et al.
Archives of Biochemistry and Biophysics, 2017
Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.
Mandel H et al.
Journal of Medical Genetics, 2016
Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter.
Liu D et al.
International Journal of Molecular Sciences, 2016
HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis.
Goo HG et al.
Experimental Cell Research, 2014
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.
Cilenti L et al.
Biochimica Et Biophysica Acta, 2014
HTRA2 variations in Taiwanese Parkinson's disease.
Chen CM et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2014
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Patterson VL et al.
Plos One, 2014
HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.
Goo HG et al.
Biochimica Et Biophysica Acta, 2013
A novel role for the mitochondrial HTRA2/OMI protease in aging.
Kang S et al.
Autophagy, 2013
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease.
Westerlund M et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2011
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.
Li B et al.
Cell Death and Differentiation, 2010
Association of Omi/HtrA2 with γ-secretase in mitochondria.
Behbahani H et al.
Neurochemistry International, 2010
HtrA2, taming the oncogenic activities of WT1.
Hartkamp J et al.
Cell Cycle (georgetown, Tex.), 2010
Cyclophilin D-dependent mitochondrial permeability transition is not involved in neurodegeneration in mnd2 mutant mice.
Ideguchi K et al.
Biochemical and Biophysical Research Communications, 2010
The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity.
Park HM et al.
Biochemical and Biophysical Research Communications, 2009
Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.
Johnson F et al.
Plos One, 2009
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo.
Yun J et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2008
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.
Simón-Sánchez J et al.
Human Molecular Genetics, 2008
The mitochondrial serine protease HtrA2/Omi: an overview.
Vande Walle L et al.
Cell Death and Differentiation, 2008
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.
Huttunen HJ et al.
The Journal of Biological Chemistry, 2007
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Strauss KM et al.
Human Molecular Genetics, 2005
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
Gupta S et al.
The Journal of Biological Chemistry, 2004
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.
Jones JM et al.
Nature, 2003