Associated Papers
HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis.
Ikeda T et al.
Cell Reports, 2025
Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1.
Warner K et al.
Cell Reports, 2025
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance.
McKenna JK et al.
Plos Genetics, 2025
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.
Monda JK et al.
Cell Reports, 2023
HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates.
Zhou M et al.
Biorxiv : the Preprint Server for Biology, 2023
The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1.
Mueller S et al.
Plos One, 2023
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Hunkeler M et al.
Molecular Cell, 2021
Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.
Cassidy KB et al.
The Febs Journal, 2020
A conformational switch regulates the ubiquitin ligase HUWE1.
Sander B et al.
Elife, 2017
Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.
Cheng YF et al.
The Journal of Biological Chemistry, 2016
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