Associated Papers
The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1.
Mueller S et al.
Plos One, 2023
Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells.
Fan L et al.
Cell Death & Disease, 2020
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion.
Lee HJ et al.
Nature Communications, 2019
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Myant KB et al.
Embo Molecular Medicine, 2017
K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.
Hao Z et al.
Nature Communications, 2017
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
Dominguez-Brauer C et al.
Cell Stem Cell, 2016
HUWE1 interacts with PCNA to alleviate replication stress.
Choe KN et al.
Embo Reports, 2016
DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.
Yi J et al.
Nucleic Acids Research, 2015
25883150 (PubMed )
Supplement: supp_gkv325_nar-03455-d-2014-File009.pdf
Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.
Thompson JW et al.
The Journal of Biological Chemistry, 2014
Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.
Dorn J et al.
The Journal of Biological Chemistry, 2014
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
Wang X et al.
Biochemical and Biophysical Research Communications, 2014
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
Wang X et al.
Biochemical and Biophysical Research Communications, 2014
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Inoue S et al.
Genes & Development, 2013
Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage.
Zhou X et al.
The Biochemical Journal, 2012
A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.
Pandya RK et al.
The Journal of Biological Chemistry, 2010
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
Zhao X et al.
Developmental Cell, 2009
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