Associated Papers
Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes.
Zhu S et al.
Biorxiv : the Preprint Server for Biology, 2023
Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins.
Yilmaz A et al.
Biomolecules, 2023
Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.
Sahoo BR et al.
Journal of Molecular Biology, 2021
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Maianti JP et al.
Nature Chemical Biology, 2019
SIRT4 regulates PTEN stability through IDE in response to cellular stresses.
Liu M et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2019
Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
Liang WG et al.
Journal of Molecular Biology, 2015
Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress.
Beuzelin C et al.
Plos One, 2013
Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.
Malito E et al.
Biochemistry, 2008
The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.
Llovera RE et al.
The Journal of Biological Chemistry, 2008
Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
Im H et al.
The Journal of Biological Chemistry, 2007
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Shen Y et al.
Nature, 2006
Functional analysis of conserved residues in the active site of insulin-degrading enzyme.
Perlman RK et al.
The Journal of Biological Chemistry, 1993
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