Associated Papers
Evaluation of an IDH1/2 Mutation FastTrack Assay for Patients with Cholangiocarcinoma.
Winter M et al.
Cancers, 2025
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M et al.
Nature Communications, 2024
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M et al.
Research Square, 2024
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M et al.
Biorxiv : the Preprint Server for Biology, 2024
Heterogeneity of the cancer cell line metabolic landscape.
Shorthouse D et al.
Molecular Systems Biology, 2022
Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin.
Woodhouse R et al.
Plos One, 2020
Loss of BCAT1 Expression is a Sensitive Marker for IDH-Mutant Diffuse Glioma.
Chen YY et al.
Neurosurgery, 2019
An olive oil phenolic is a new chemotype of mutant isocitrate dehydrogenase 1 (IDH1) inhibitors.
Verdura S et al.
Carcinogenesis, 2019
Prevalence of the single-nucleotide polymorphism rs11554137 (IDH1105GGT) in brain tumors of a cohort of Italian patients.
Acquaviva G et al.
Scientific Reports, 2018
Toward an integrated map of genetic interactions in cancer cells.
Rauscher B et al.
Molecular Systems Biology, 2018
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.
Berg KCG et al.
Molecular Cancer, 2017
IDH mutations associated impact on related cancer epidemiology and subsequent effect toward HIF-1α.
Semukunzi H et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2017
Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors.
Liu X et al.
Histology and Histopathology, 2015
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Betge J et al.
Plos One, 2015
Next-generation sequencing analysis of lung and colon carcinomas reveals a variety of genetic alterations.
Chevrier S et al.
International Journal of Oncology, 2014
Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring.
Luthra R et al.
Haematologica, 2014
New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
Ross JS et al.
The Oncologist, 2014
Mixed T/myeloid phenotype acute leukemia with rare variants of IDH1 and CEBPA.
Ma Q et al.
Leukemia & Lymphoma, 2013
Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Rendina AR et al.
Biochemistry, 2013
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.
Yang H et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2012
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.
Ward PS et al.
Oncogene, 2012
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.
Leonardi R et al.
The Journal of Biological Chemistry, 2012
Cancer-associated IDH mutations: biomarker and therapeutic opportunities.
Yen KE et al.
Oncogene, 2010
IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders.
Zou Y et al.
Biochemical and Biophysical Research Communications, 2010
IDH mutations in glioma and acute myeloid leukemia.
Dang L et al.
Trends in Molecular Medicine, 2010
Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.
Paugh BS et al.
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2010
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.
Bleeker FE et al.
Human Mutation, 2009