Associated Papers
Understanding the IDH1 missense SNPs on expression of genes involved in Glioblastoma multiforme.
Kakde GS et al.
Computational Biology and Chemistry, 2025
Blocking mutant IDH1 phosphorylation triggers APC/C CDH1-dependent ubiquitination in mitotic cells.
Swain S et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2025
Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients.
Leventoglu E et al.
Medeniyet Medical Journal, 2023
The Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas.
Zhang M et al.
Frontiers in Cell and Developmental Biology, 2021
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.
Luna LA et al.
The Biochemical Journal, 2020
IDH1 fine-tunes cap-dependent translation initiation.
Liu L et al.
Journal of Molecular Cell Biology, 2019
The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.
Wang TX et al.
Cell Death & Disease, 2019
Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Badur MG et al.
Cell Reports, 2018
Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.
Wang P et al.
Cell Reports, 2015
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
Ma S et al.
Oncotarget, 2015
Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Yang B et al.
Cell Research, 2010
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