Associated Papers
β1-integrin controls IGF-1R internalization and intracellular signaling.
McDermott N et al.
The Journal of Biological Chemistry, 2025
Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth.
Kelly GM et al.
The Journal of Biological Chemistry, 2012
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Kiely PA et al.
The Journal of Biological Chemistry, 2009
Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.
Kiely PA et al.
The Journal of Biological Chemistry, 2008
RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.
Kiely PA et al.
The Journal of Biological Chemistry, 2005
Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251.
Leahy M et al.
The Journal of Biological Chemistry, 2004
14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner.
Craparo A et al.
The Journal of Biological Chemistry, 1997
Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.
Li S et al.
The Journal of Biological Chemistry, 1996
Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.
Jiang Y et al.
The Journal of Biological Chemistry, 1996
Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor.
Miura M et al.
The Journal of Biological Chemistry, 1995
Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells.
Miura M et al.
Cancer Research, 1995
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