Varaico: Literature-Extracted Genetic Variants

Gene:IKBKG
Variant:p.K285R
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IKBKG

NM_001099857.5:p.K285R

Associated Papers

NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.

Furthmann N et al.

Nature Communications, 2023

Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling.

Goel S et al.

Life Science Alliance, 2023

36720498 (PubMed )
Supplement: LSA-2022-01607_review_history.pdf

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.

Müller-Rischart AK et al.

Molecular Cell, 2013

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.

Niu J et al.

The Embo Journal, 2011

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

Hinz M et al.

Molecular Cell, 2010

TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL.

Walsh MC et al.

Plos One, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."