Varaico: Literature-Extracted Genetic Variants

Gene:IKBKG
Variant:p.Y308S
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IKBKG

NM_001099857.5:p.Y308S

Associated Papers

Covalent modification of the NF-κB essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro.

Hooper C et al.

The Journal of Biological Chemistry, 2014

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.

Liu S et al.

Elife, 2013

NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.

Wang L et al.

Plos One, 2012

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

Hinz M et al.

Molecular Cell, 2010

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

Wu ZH et al.

Molecular Cell, 2010

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.

Laplantine E et al.

The Embo Journal, 2009

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.

Oeckinghaus A et al.

The Embo Journal, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."