Varaico: Literature-Extracted Genetic Variants

Gene:IKBKG
Variant:p.K309R
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IKBKG

NM_001099857.5:p.K309R

Associated Papers

NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.

Furthmann N et al.

Nature Communications, 2023

Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling.

Goel S et al.

Life Science Alliance, 2023

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.

Shao L et al.

Nature Communications, 2015

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.

Müller-Rischart AK et al.

Molecular Cell, 2013

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.

Niu J et al.

The Embo Journal, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."