Associated Papers
H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability.
Rysan H et al.
Journal of Leukocyte Biology, 2026
IKAROS regulates human T cell phenotype at a thymic and postthymic level.
Stoddard J et al.
Jci Insight, 2025
A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development.
Okuyama K et al.
Nature Immunology, 2024
Aiolos promotes CXCR3 expression on Th1 cells via positive regulation of IFN-γ/STAT1 signaling.
Leonard MR et al.
Jci Insight, 2024
AIOLOS-Associated Inborn Errors of Immunity.
Yamashita M et al.
Journal of Clinical Immunology, 2024
Identification and Functional Analysis of a de novo IKZF3 Mutation in a Pediatric Patient with Combined Immunodeficiency.
Shi X et al.
Journal of Clinical Immunology, 2024
IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.
Rodrigues de Oliveira B et al.
Gene, 2024
Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains.
Kuehn HS et al.
The Journal of Clinical Investigation, 2024
A Rare AIOLOS N160S Variant Causing IEI in Human.
Özdemir Ö et al.
Journal of Clinical Immunology, 2024
Inborn errors of human B cell development, differentiation, and function.
Tangye SG et al.
The Journal of Experimental Medicine, 2023
Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function.
Chang J et al.
Frontiers in Immunology, 2023
AIOLOS Variants Causing Immunodeficiency in Human and Mice.
Yamashita M et al.
Frontiers in Immunology, 2022
T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.
Kuehn HS et al.
The Journal of Experimental Medicine, 2021
A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.
Yamashita M et al.
Nature Immunology, 2021
IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.
Barrio S et al.
Haematologica, 2020
N160 of Aiolos Determines its DNA-Binding Activity.
Wang H et al.
Anatomical Record (hoboken, N.j. : 2007), 2019
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