Associated Papers
Enhanced affinity for the IL-2 receptor β subunit potently increases antitumor efficacy of IL-2 across various tumor models by reshaping the tumor microenvironment.
Relova-Hernández E et al.
Journal of Immunology (baltimore, Md. : 1950), 2025
Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network.
Woodward CH et al.
Journal of Molecular Biology, 2025
Regulating IL-2 immune signaling function via a core allosteric structural network.
Woodward CH et al.
Biorxiv : the Preprint Server for Biology, 2024
Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by β-strand slippage.
Katzschmann A et al.
Communications Biology, 2024
A novel dual mechanism-of-action bispecific PD-1-IL-2v armed by a "βγ-only" interleukin-2 variant.
Jiang Y et al.
Frontiers in Immunology, 2024
Expanding the clinical utility of therapeutic proteins: activated protein C variants with improved pharmacological properties.
Vasserot AP et al.
Trends in Pharmacological Sciences, 2003
Locating the unpaired cysteine of tissue-type plasminogen activator.
Sehl LC et al.
Protein Engineering, 1996
Engineered interleukin-2 antagonists for the inhibition of regulatory T cells.
Liu DV et al.
Journal of Immunotherapy (hagerstown, Md. : 1997), 0
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