Varaico: Literature-Extracted Genetic Variants

Gene:IL4R
Variant:p.S503P
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IL4R

NM_000418.4:p.S503P

Associated Papers

Nonsteroidal anti-inflammatory drug-induced acute urticaria/angioedema associated with atopy-related genes' genetic variants.

Jiménez-Sánchez IM et al.

The Journal of Allergy and Clinical Immunology, 2026

Study the role of interleukin-4 and interferon- in patients with penicillin allergy.

Al-Omari RSM et al.

The Egyptian Journal of Immunology, 2026

Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis.

Perälä M et al.

Jid Innovations : Skin Science From Molecules to Population Health, 2023

37533579 (PubMed )
Supplement: mmc1.xlsx › Supplementary_Table_S1

Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.

Ariff A et al.

Malaria Journal, 2023

Biochemical Characteristics of iPSC-Derived Dopaminergic Neurons from N370S GBA Variant Carriers with and without Parkinson's Disease.

Grigor'eva EV et al.

International Journal of Molecular Sciences, 2023

36901867 (PubMed )
Supplement: ijms-24-04437-s001.zip › ijms-2163006-supplementary.pdf

Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations.

Juskevicius D et al.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 2023

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM1_ESM.xlsx › sheet_1

Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation.

Lonjou C et al.

Bmc Cancer, 2017

28499365 (PubMed )
Supplement: 12885_2017_3314_MOESM1_ESM.xls › SupplTableS1.xls

Gene polymorphisms of stress hormone and cytokine receptors associate with immunomodulatory profile and psychological measurement.

Xiang L et al.

Journal of Psychosomatic Research, 2015

Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis.

Hämäläinen S et al.

Bmc Musculoskeletal Disorders, 2014

Interleukin-4 receptor α-chain polymorphisms and susceptibility to allergic rhinitis: a meta-analysis.

Xu Y et al.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-rhino-laryngological Societies (eufos) : Affiliated With the German Society for Oto-rhino-laryngology - Head and Neck Surgery, 2014

Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA).

Tavasolian F et al.

Journal of Assisted Reproduction and Genetics, 2014

Associations between cytokine receptor polymorphisms and variability in laboratory immune parameters in normal humans.

Xiang L et al.

Human Immunology, 2014

Symptom clusters of pain, depressed mood, and fatigue in lung cancer: assessing the role of cytokine genes.

Reyes-Gibby CC et al.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 2013

Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations.

Ingram N et al.

Carcinogenesis, 2013

Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: The Kyushu Okinawa Maternal and Child Health Study.

Miyake Y et al.

Scandinavian Journal of Immunology, 2013

Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.

Ovsyannikova IG et al.

Gene, 2012

Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma.

Chu H et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2012

Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans.

Zhang L et al.

Hepatology (baltimore, Md.), 2012

Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population.

Pál Z et al.

Human Immunology, 2012

Associations between three polymorphisms in the interleukin-4 receptor gene and risk of cancer: a meta-analysis.

Wang JY et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2012

A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis.

Wallis SK et al.

Arthritis Research & Therapy, 2011

Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis.

Knutsen AP et al.

Clinical & Developmental Immunology, 2011

Immunopathology and immunogenetics of allergic bronchopulmonary aspergillosis.

Knutsen AP

Journal of Allergy, 2011

Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

Hildebrandt MA et al.

Plos One, 2010

Genetic and ethnic risk factors associated with drug hypersensitivity.

Kim SH et al.

Current Opinion in Allergy and Clinical Immunology, 2010

Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.

Beckers MM et al.

European Journal of Internal Medicine, 2010

Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.

Vargiolu M et al.

Osteoarthritis and Cartilage, 2010

Association of Q551R polymorphism in the interleukin 4 receptor gene with nonatopic asthma in Slovenian children.

Berce V et al.

Wiener Klinische Wochenschrift, 2010

Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.

Knutsen AP et al.

Clinical and Molecular Allergy : Cma, 2010

Association analysis of SNPs in the IL4R locus with type I diabetes.

Erlich HA et al.

Genes and Immunity, 2009

Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians.

Trajkov D et al.

Clinical Rheumatology, 2009

Role of inflammation gene polymorphisms on pain severity in lung cancer patients.

Reyes-Gibby CC et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2009

Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial.

Schoof N et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2009

An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation.

Ford AQ et al.

Journal of Immunology (baltimore, Md. : 1950), 2009

Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.

Driss A et al.

Genomics Insights, 2009

Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women.

Van Dyke AL et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2009

Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

Van Dyke AL et al.

Cytokine, 2009

Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.

Ryu GM et al.

Nucleic Acids Research, 2009

19139070 (PubMed )
Supplement: gkn1008_nar-01723-s-2008-File009.xls › TypeI-

Genetic etiologies for phenotypic diversity in sickle cell anemia.

Steinberg MH

Thescientificworldjournal, 2009

Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

Weidinger S et al.

Plos Genetics, 2008

18846228 (PubMed )
Supplement: pgen.1000166.s014.doc

A variant of the IL4 I50V single-nucleotide polymorphism is associated with erosive joint disease in psoriatic arthritis.

Rahman P et al.

Arthritis and Rheumatism, 2008

Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer.

Ivansson EL et al.

International Journal of Cancer, 2007

Correlation between some Th1 and Th2 cytokine receptor gene polymorphisms and systemic lupus erythematosus in Chinese patients.

Xu Y et al.

International Journal of Dermatology, 2007

Association of IL4R gene polymorphisms with asthma in Chinese populations.

Zhang H et al.

Human Mutation, 2007

Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia.

Hoppe C et al.

Stroke, 2007

Allergy-related polymorphisms influence glioma status and serum IgE levels.

Wiemels JL et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2007

Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk.

Landi S et al.

European Journal of Cancer (oxford, England : 1990), 2007

Sickle cell disease: a multigenic perspective of a single gene disorder.

Kutlar A

Hemoglobin, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."