Varaico: Literature-Extracted Genetic Variants

Gene:IL4R
Variant:p.Q576R
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IL4R

NM_000418.4:p.Q576R

Associated Papers

Nonsteroidal anti-inflammatory drug-induced acute urticaria/angioedema associated with atopy-related genes' genetic variants.

Jiménez-Sánchez IM et al.

The Journal of Allergy and Clinical Immunology, 2026

Study the role of interleukin-4 and interferon- in patients with penicillin allergy.

Al-Omari RSM et al.

The Egyptian Journal of Immunology, 2026

Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression.

Gagoski D et al.

Protein Science : a Publication of the Protein Society, 2025

41088778 (PubMed )
Supplement: PRO-34-e70317-s008.xlsx › _S6_-_PTMVar_-_Lyn

Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores.

Trimarchi MP et al.

Research Square, 2025

Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity.

Girdhar N et al.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace, 2025

Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression.

Gagoski D et al.

Biorxiv : the Preprint Server for Biology, 2025

39764007 (PubMed )
Supplement: media-1.xlsx › _S6_-_PTMVar_-_Lyn

Genetic Variant rs1801275 in Atopic Dermatitis: Prevalence and Clinical Implications in Vietnamese Population.

Nguyen THN et al.

Journal of Asthma and Allergy, 2025

Cytokine signaling defects in primary atopic diseases-an updated review.

Thakur V et al.

Frontiers in Allergy, 2025

Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis.

Tan IL et al.

Cell Reports, 2023

37917583 (PubMed )
Supplement: NIHMS1948186-supplement-2.xlsx › All-Pat-ClinVar_Coding

Genetic association of beta-lactams-induced hypersensitivity reactions: A systematic review of genome-wide evidence and meta-analysis of candidate genes.

Lumkul L et al.

The World Allergy Organization Journal, 2023

Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis.

K J et al.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace, 2023

Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis.

Perälä M et al.

Jid Innovations : Skin Science From Molecules to Population Health, 2023

37533579 (PubMed )
Supplement: mmc1.xlsx › Supplementary_Table_S1

Biochemical Characteristics of iPSC-Derived Dopaminergic Neurons from N370S GBA Variant Carriers with and without Parkinson's Disease.

Grigor'eva EV et al.

International Journal of Molecular Sciences, 2023

36901867 (PubMed )
Supplement: ijms-24-04437-s001.zip › ijms-2163006-supplementary.pdf

Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations.

Juskevicius D et al.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 2023

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM1_ESM.xlsx › sheet_1

Association of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.

Chen X et al.

African Health Sciences, 2022

Polymorphisms and AR: A Systematic Review and Meta-Analyses.

Xiang F et al.

Frontiers in Genetics, 2022

Interleukin 4 and Interleukin 4 receptor alpha gene variants and risk of atopy - A case control study based assessment.

Qurashi TA et al.

Clinical Immunology (orlando, Fla.), 2021

Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children.

Elsaid A et al.

Clinical Biochemistry, 2021

Clinical Impact of Inherited and Acquired Genetic Variants in Mastocytosis.

Nedoszytko B et al.

International Journal of Molecular Sciences, 2021

Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis.

Tanaka K et al.

The Journal of Veterinary Medical Science, 2020

Polymorphisms in the interleukin 4 receptor and interleukin 13 genes in immediate allergic reactions to beta-lactam antibiotics: A case-control study.

Ksouri L et al.

Asian Pacific Journal of Allergy and Immunology, 2019

Introducing the first whole genomes of nationals from the United Arab Emirates.

AlSafar HS et al.

Scientific Reports, 2019

31604968 (PubMed )
Supplement: 41598_2019_50876_MOESM1_ESM.xlsx › UAE_S002

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A.

Oetting WS et al.

Transplantation, 2019

Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review.

Cao Z et al.

Audiology & Neuro-otology, 2019

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study.

Borilova Linhartova P et al.

European Journal of Oral Sciences, 2018

Inflammatory Gene Polymorphisms in Lung Cancer Susceptibility.

Eaton KD et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

Genetics of acute rejection after kidney transplantation.

Dorr CR et al.

Transplant International : Official Journal of the European Society for Organ Transplantation, 2018

An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies.

Zhao J et al.

Genome Medicine, 2018

Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation.

Lonjou C et al.

Bmc Cancer, 2017

28499365 (PubMed )
Supplement: 12885_2017_3314_MOESM1_ESM.xls › SupplTableS1.xls

Impact of interleukin 13 (IL13) genetic polymorphism Arg130Gln on total serum immunoglobulin (IgE) levels and interferon (IFN)-γ gene expression.

Smolkova B et al.

Clinical and Experimental Immunology, 2017

Interleukin-31 Polymorphisms and Serum IL-31 Level in Patients with Mastocytosis: Correlation with Clinical Presen-tation and Pruritus.

Lange M et al.

Acta Dermato-venereologica, 2017

Association of IL4 and IL4R polymorphisms with multiple sclerosis susceptibility in Caucasian population: A meta-analysis.

Zhang Z et al.

Journal of the Neurological Sciences, 2016

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.

Oussalah A et al.

Allergy, 2016

Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium.

Lupiañez CB et al.

Infection and Immunity, 2015

A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults.

Davoodi P et al.

The Indian Journal of Medical Research, 2015

Anaphylaxis with clonal mast cells in normal looking skin - a new entity?

Bretterklieber A et al.

Allergy, 2015

Gene polymorphisms of stress hormone and cytokine receptors associate with immunomodulatory profile and psychological measurement.

Xiang L et al.

Journal of Psychosomatic Research, 2015

Association of the IL-4R Q576R polymorphism and asthma in the Chinese Han population: a meta-analysis.

Huang ZY et al.

Genetics and Molecular Research : Gmr, 2015

Complement C5a receptor gene 450 C/T polymorphism in renal transplant recipients: association of the CT genotype with graft outcome.

Günesacar R et al.

Tissue Antigens, 2015

[Correlation of gene polymorphism of interleukin 4 receptor alpha peptide chain and total serum IgE levels in asthmatic children in Guiyang area].

Zheng S et al.

Zhonghua Yi Xue Za Zhi, 2014

Interleukin-4 receptor α-chain polymorphisms and susceptibility to allergic rhinitis: a meta-analysis.

Xu Y et al.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-rhino-laryngological Societies (eufos) : Affiliated With the German Society for Oto-rhino-laryngology - Head and Neck Surgery, 2014

Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA).

Tavasolian F et al.

Journal of Assisted Reproduction and Genetics, 2014

Interleukin-4RA gene polymorphism is associated with oral mucous membrane pemphigoid.

Carrozzo M et al.

Oral Diseases, 2014

IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population.

Al-Muhsen S et al.

Annals of Thoracic Medicine, 2014

Associations between cytokine receptor polymorphisms and variability in laboratory immune parameters in normal humans.

Xiang L et al.

Human Immunology, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."