Varaico: Literature-Extracted Genetic Variants

Gene:IL6
Variant:p.K199K
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IL6

NM_000600.5:p.K199K

Associated Papers

Association of IL6 Gene Polymorphisms with COVID-19 Susceptibility and Inflammation in Pregnant Women.

Ben Dhifallah I et al.

Diseases (basel, Switzerland), 2026

Genetic polymorphisms in headache attributed to temporomandibular disorder: A case-control study.

Campello CP et al.

Archives of Oral Biology, 2026

IL-6 and TNF variants as potential determinants of perianal disease in Crohn's patients: a pilot study.

Cusato J et al.

Cytokine, 2025

Association of polycystic ovarian syndrome with inflammatory single nucleotide polymorphism for IL-1 & IL-6 genes: A case-control study.

Benjamin JJ et al.

The Indian Journal of Medical Research, 2025

Impact of IL-6 Promotor AnTn Polymorphism on Blood IL-6 Levels and Pregnancy Outcome in Toxoplasma gondii Infected Women.

Khan MB et al.

Parasite Immunology, 2025

Genetic polymorphisms associated with periodontitis in Japanese populations: A comprehensive review of pathways, interactions, and clinical implications.

Ferrara E et al.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 2025

Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study.

Izakovicova P et al.

Journal of Diabetes Investigation, 2025

Protective Genes Against Alzheimer's Disease: Case Review and Therapeutic Implications.

Hossain N et al.

Dementia and Neurocognitive Disorders, 2025

Association of VDR and TMPRSS2 gene polymorphisms with COVID-19 severity: a computational and clinical study.

Verma S et al.

Molecular Biology Reports, 2025

Impact of IL-6 rs1800795 and rs1800796 polymorphisms on clinical outcomes of COVID-19: a study on severity of disease in Turkish population.

Cekin N et al.

Mammalian Genome : Official Journal of the International Mammalian Genome Society, 2025

Association of IL6 Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis.

Harun-Or-Roshid M et al.

Neuromolecular Medicine, 2025

The role of inflammatory gene polymorphisms in severe COVID-19: a review.

Yip JQ et al.

Virology Journal, 2024

Systematic Review of IL-1, IL-4, IL-6, IL-10, IL-15, and IL-18 Gene Polymorphisms and Meta-Analysis of IL-6 Variant and Its Association with Overweight and Obesity Risk in Men.

Bojarczuk A et al.

International Journal of Molecular Sciences, 2024

IL-6-174 G/C transversion might decrease male infertility risk: A case-control study.

Zamani-Badi T et al.

International Journal of Reproductive Biomedicine, 2024

Role of interleukin 6 polymorphism and inflammatory markers in outcome of pediatric Covid- 19 patients.

AbdelAziz RA et al.

Bmc Pediatrics, 2024

Genetic Polymorphism of Interleukin-6 in Asymptomatic and ICU-Admitted COVID-19 Patients in Sulaymaniyah Province, Kurdistan Region of Iraq.

Rashid PMA et al.

Genetic Testing and Molecular Biomarkers, 2024

Auditory Neuropathy Spectrum Disorder in Individuals with Sickle Cell Anemia: Case Study.

Sahu P et al.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India, 2024

Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis.

Coimbra S et al.

Biomedicines, 2024

The Interleukin-6 gene variants may protect against SARS-CoV-2 infection and the severity of COVID-19: a case-control study in a Moroccan population.

Noureddine R et al.

Bmc Medical Genomics, 2024

No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients.

Dmytrzak A et al.

International Journal of Molecular Sciences, 2024

Association between interleukin-6-174G/C gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation.

Al-Ahmad M et al.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2024

Determination of IL-6 Gene Promoter Polymorphism in Patients with Hepatitis C and Its Impact on RNA Secondary Structure.

Sadiq S et al.

Medicina (kaunas, Lithuania), 2024

Analysis of interleukin-6 gene polymorphism and its serum levels in Indian age-related macular degeneration patients.

Yadav A et al.

Molecular Vision, 2024

Correlation of TGF-β signaling pathway gene polymorphisms with unexplained recurrent spontaneous abortion.

Xue H et al.

Medicine, 2023

Association between gene polymorphism of inflammatory factors, thrombogenic factors, and stress-related proteins and abdominal aortic aneurysm: A meta-analysis and systematic review.

Weng Y et al.

Vascular, 2023

Genetic polymorphism between the Sorani and Hawrami kurdish populations and COVID-19 outcome.

Rashid PMA et al.

Molecular Biology Reports, 2023

Association of Interleukin-6 Polymorphisms with Schizophrenia and Depression: A Case-Control Study.

Lu D et al.

Laboratory Medicine, 2023

Correlations of IL-6 and TGF-β Gene Polymorphisms and Expressions With Osteoporotic, Thoracolumbar, Vertebral Compression Fracture.

Zuo T et al.

Alternative Therapies in Health and Medicine, 2023

Genetic polymorphisms of TNF-α, IL-6, and IL-10 in female elderly patients with chronic temporomandibular disorder pain.

Campello CP et al.

Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 2023

Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity.

Verma S et al.

International Journal of Immunogenetics, 2023

Genetic Variants Associated with Acne Vulgaris.

Zhang H et al.

International Journal of General Medicine, 2023

Evaluation the -174G>C Genetic Polymorphism of Interleukin-6 in Iranian Patients with Chronic Lymphocytic Leukemia.

Rostamzadeh Khameneh Z et al.

Iranian Journal of Pathology, 2023

Genotypic and haplotype analysis of Interleukin-6 and -18 gene polymorphisms in association with clinicopathological factors in breast cancer.

Padala C et al.

Cytokine, 2022

IL-1 β gene (+3954 C/T, exon 5, rs1143634) and NOS2 (exon 22) polymorphisms associate with early aseptic loosening of arthroplasties.

López-Anglada E et al.

Scientific Reports, 2022

Variants of Th17 pathway-related genes influence brain morphometric changes and the risk of schizophrenia through epistatic interactions.

Subbanna M et al.

Psychiatric Genetics, 2022

Interaction of Interleukin 7 Receptor (IL7R) and IL6 Gene Polymorphisms with Smoking Associated with Susceptibility to Asthma in Chinese Han Adults.

Du JW et al.

Immunological Investigations, 2022

Evaluation of the relationship between IL-6 gene single nucleotide polymorphisms and the severity of COVID-19 in an Iranian population.

Falahi S et al.

Cytokine, 2022

Polymorphism in promotor region of IL6 gene as a predictor for severity in COVID -19 patients.

Aladawy SA et al.

The Egyptian Journal of Immunology, 2022

Polymorphisms in Human IL4, IL10, and TNF Genes Are Associated with an Increased Risk of Developing NSAID-Exacerbated Respiratory Disease.

Reigada-Rivera ML et al.

Genes, 2022

Proinflammatory Cytokines (IL-1, -6, -8, -15, -17, -18, -23, TNF-α) Single Nucleotide Polymorphisms in Rheumatoid Arthritis-A Literature Review.

Koper-Lenkiewicz OM et al.

International Journal of Molecular Sciences, 2022

A review of key cytokines based on gene polymorphism in the pathogenesis of pre-eclampsia.

Guan C et al.

American Journal of Reproductive Immunology (new York, N.y. : 1989), 2022

Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis.

Yang Y et al.

Frontiers in Genetics, 2022

Association of IL-6 and TGF-β Gene Polymorphisms with the Risk of Thoracolumbar Osteoporotic Vertebral Compression Fractures.

Xiong Y et al.

Pharmacogenomics and Personalized Medicine, 2022

Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis.

Dieter C et al.

Plos One, 2022

35793369 (PubMed )
Supplement: pone.0270627.s002.xlsx › Planilha1

Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis.

Rai H et al.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], 2021

Association between single nucleotide polymorphisms of IL-6 and susceptibility to skin cancer: a meta-analysis and systematic review.

Guo K et al.

Translational Cancer Research, 2021

Frequency of Interleukin-6 rs1800795 (-174G/C) and rs1800797 (-597G/A) Polymorphisms in COVID-19 Patients in Turkey Who Develop Macrophage Activation Syndrome.

Kerget F et al.

Japanese Journal of Infectious Diseases, 2021

A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19.

Chen T et al.

Mbio, 2021

The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer.

Martínez-Pérez C et al.

Journal of Personalized Medicine, 2021

The association between interleukin-6 promoter polymorphisms and rheumatoid arthritis by ethnicity: A meta-analysis of 33 studies.

Pacheco-Soto BT et al.

Reumatologia Clinica, 2021

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."