Varaico: Literature-Extracted Genetic Variants

Gene:IL6R
Variant:p.D281V
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IL6R

NM_000565.4:p.D281V

Associated Papers

Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.

Salvati AL et al.

The Journal of Biological Chemistry, 1995

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Paonessa G et al.

The Embo Journal, 1995

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

Yawata H et al.

The Embo Journal, 1993

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."