Associated Papers
A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression.
Gaggioli MR et al.
Cell Reports, 2025
40188438 (PubMed )
Supplement: mmc1.pdf
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.
Béziat V et al.
The Journal of Experimental Medicine, 2020
Oncogenic deletion mutants of gp130 signal from intracellular compartments.
Schmidt-Arras D et al.
Journal of Cell Science, 2014
Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.
Poussin K et al.
Oncoimmunology, 2013
IL-6 and IL-11 as markers for tumor aggressiveness and prognosis in gastric adenocarcinoma patients without mutations in Gp130 subunits.
Necula LG et al.
Journal of Gastrointestinal and Liver Diseases : Jgld, 2012
SHP-2 tyrosine phosphatase in human diseases.
Zheng H et al.
International Journal of Clinical and Experimental Medicine, 2009
c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130.
Tanaka Y et al.
Molecular and Cellular Biology, 2008
SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.
Sobota RM et al.
Cellular Signalling, 2008
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
Sawa S et al.
The Journal of Experimental Medicine, 2006
SHP2 forecast for the immune system: fog gradually clearing.
Salmond RJ et al.
Trends in Immunology, 2006
The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.
Jenkins BJ et al.
Blood, 2005
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
Fischer P et al.
The Biochemical Journal, 2004
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.
Fairlie WD et al.
The Biochemical Journal, 2003
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
Tebbutt NC et al.
Nature Medicine, 2002
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
Schaper F et al.
The Biochemical Journal, 1998
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