Varaico: Literature-Extracted Genetic Variants

Gene:ILK
Variant:p.E359K
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ILK

NM_004517.4:p.E359K

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5

The ILK-PINCH-parvin complex: a conserved primary adhesome regulating biological processes.

Ain U et al.

Histochemistry and Cell Biology, 2025

The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer.

Ji C et al.

Cell Death & Disease, 2022

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

El Kharbili M et al.

Oncotarget, 2017

Modulation of type II TGF-β receptor degradation by integrin-linked kinase.

Vi L et al.

The Journal of Investigative Dermatology, 2015

Integrin-linked kinase: not so 'pseudo' after all.

Hannigan GE et al.

Oncogene, 2011

A central multifunctional role of integrin-linked kinase at muscle attachment sites.

Zervas CG et al.

Journal of Cell Science, 2011

Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.

Spinella F et al.

Plos One, 2010

JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma.

Durbin AD et al.

The Journal of Clinical Investigation, 2009

Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease.

Werner C et al.

Biochemical and Biophysical Research Communications, 2008

Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex.

Postel R et al.

Developmental Biology, 2008

Interaction of integrin-linked kinase with the kidney chloride/bicarbonate exchanger, kAE1.

Keskanokwong T et al.

The Journal of Biological Chemistry, 2007

Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart.

Bendig G et al.

Genes & Development, 2006

The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction.

Yoshimi R et al.

Journal of Immunology (baltimore, Md. : 1950), 2006

The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner.

Khyrul WA et al.

The Journal of Biological Chemistry, 2004

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation.

Sakai T et al.

Genes & Development, 2003

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes.

Mackinnon AC et al.

Current Biology : Cb, 2002

Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization.

Nikolopoulos SN et al.

The Journal of Biological Chemistry, 2002

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.

Yamaji S et al.

The Journal of Cell Biology, 2001

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane.

Zervas CG et al.

The Journal of Cell Biology, 2001

Integrin-linked kinase (ILK): a "hot" therapeutic target.

Yoganathan TN et al.

Biochemical Pharmacology, 2000

Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice.

Bulus N et al.

The Journal of Biological Chemistry, 0

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