Varaico: Literature-Extracted Genetic Variants

Gene:IRAK1
Variant:p.D340N
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IRAK1

NM_001569.4:p.D340N

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5

Characterization, expression, and functional study of IRAK-1 from grouper, Epinephelus coioides.

Li YW et al.

Fish & Shellfish Immunology, 2016

A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.

Bruni D et al.

Journal of Immunology (baltimore, Md. : 1950), 2013

IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.

Muroi M et al.

Biochimica Et Biophysica Acta, 2012

The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.

Wang D et al.

Molecular Immunology, 2008

Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity.

Böl GF et al.

Biochemical and Biophysical Research Communications, 2005

IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.

Huang Y et al.

The Journal of Biological Chemistry, 2004

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.

Burns K et al.

The Journal of Experimental Medicine, 2003

Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus.

Böl G et al.

Febs Letters, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."