Varaico: Literature-Extracted Genetic Variants

Gene:IRAK1
Variant:p.T66A
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IRAK1

NM_001569.4:p.T66A

Associated Papers

Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation.

Neumann D et al.

Journal of Leukocyte Biology, 2008

NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ.

Heckscher ES et al.

Neuron, 2007

The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.

Neumann D et al.

Biochemical and Biophysical Research Communications, 2007

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling.

Lasker MV et al.

Journal of Immunology (baltimore, Md. : 1950), 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."