Associated Papers
Integrating epidemiology and genomics data to estimate the prevalence of acquired cysteine drug targets in the U.S. cancer patient population.
Arun AS et al.
The Pharmacogenomics Journal, 2025
40044654 (PubMed )
Supplement: 41397_2025_364_MOESM3_ESM.xlsx › Sheet1
Inherited IRAK-4 Deficiency in Acute Human Herpesvirus-6 Encephalitis.
Tepe ZG et al.
Journal of Clinical Immunology, 2023
IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation.
Nishimura S et al.
Journal of Clinical Immunology, 2021
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Fragoza R et al.
Nature Communications, 2019
31515488 (PubMed )
Supplement: 41467_2019_11959_MOESM11_ESM.xlsx › SD7_-_Drug_Targets
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex.
Zaro BW et al.
Journal of Immunology (baltimore, Md. : 1950), 2019
Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.
De S et al.
The Journal of Biological Chemistry, 2018
The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.
Dossang AC et al.
Scientific Reports, 2016
Rare mendelian primary immunodeficiency diseases associated with impaired NF-κB signaling.
Paciolla M et al.
Genes and Immunity, 2015
Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.
Yamamoto T et al.
Molecular Immunology, 2014
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.
Picard C et al.
Medicine, 2010
Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.
Krause JC et al.
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 2009
TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.
Hoarau C et al.
Journal of Immunology (baltimore, Md. : 1950), 2007
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