Associated Papers
The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways.
Pereira M et al.
Cell Reports, 2022
Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.
Lange SM et al.
Structure (london, England : 1993), 2021
Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.
De S et al.
The Journal of Biological Chemistry, 2018
Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1.
Nanda SK et al.
Journal of Immunology (baltimore, Md. : 1950), 2016
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