Associated Papers
Cysteine allostery and autoinhibition govern human STING oligomer functionality.
Chan R et al.
Nature Chemical Biology, 2025
IRF3-p300 axis controls global acetylation and mitotic progression.
Kim WJ et al.
Biochemical and Biophysical Research Communications, 2025
Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity.
Hu L et al.
Iscience, 2021
Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization.
Dalskov L et al.
Nucleic Acids Research, 2020
The Structural Basis of IRF-3 Activation upon Phosphorylation.
Jing T et al.
Journal of Immunology (baltimore, Md. : 1950), 2020
A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation.
Peng D et al.
Journal of Immunology (baltimore, Md. : 1950), 2017
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Liu S et al.
Science (new York, N.y.), 2015
Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.
Takahasi K et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2010
X-ray crystal structure of IRF-3 and its functional implications.
Takahasi K et al.
Nature Structural Biology, 2003
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