Varaico: Literature-Extracted Genetic Variants

Gene:IRF3
Variant:p.S385A
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IRF3

NM_001571.6:p.S385A

Associated Papers

Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.

Meng F et al.

Molecular Cell, 2021

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.

Xing J et al.

Nature Communications, 2021

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

Liu S et al.

Science (new York, N.y.), 2015

Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.

Takahasi K et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2010

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.

Panne D et al.

The Journal of Biological Chemistry, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."