Varaico: Literature-Extracted Genetic Variants

Gene:IRF3
Variant:p.R285Q
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IRF3

NM_001571.6:p.R285Q

Associated Papers

Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity.

Idorn M et al.

The Journal of Experimental Medicine, 2026

Monogenic disorders of the IRF transcription factors.

Stojcic MP et al.

The Journal of Experimental Medicine, 2026

Interferons in human inborn errors of disease.

Stine L et al.

Mbio, 2025

Inborn Errors of Immunity Predisposing to Herpes Simplex Virus Infections of the Central Nervous System.

Skouboe MK et al.

Pathogens (basel, Switzerland), 2023

Toll-Like Receptor Signaling in the Establishment and Function of the Immune System.

Aluri J et al.

Cells, 2021

Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization.

Dalskov L et al.

Nucleic Acids Research, 2020

The Structural Basis of IRF-3 Activation upon Phosphorylation.

Jing T et al.

Journal of Immunology (baltimore, Md. : 1950), 2020

Identification and characterization of rare toll-like receptor 3 variants in patients with autoimmune Addison's disease.

Aslaksen S et al.

Journal of Translational Autoimmunity, 2019

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

Andersen LL et al.

Genes and Immunity, 2019

IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies.

Mogensen TH

Frontiers in Immunology, 2018

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

Andersen LL et al.

The Journal of Experimental Medicine, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."