Varaico: Literature-Extracted Genetic Variants

Gene:IRF4
Variant:p.L116R
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IRF4

NM_002460.4:p.L116R

Associated Papers

Genomic determinants of response and resistance to pirtobrutinib in relapsed/refractory chronic lymphocytic leukemia.

Brown JR et al.

Blood, 2026

41055698 (PubMed )
Supplement: BLOOD_BLD-2024-027009-mmc4.xlsx › Sheet_1

Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.

Wang G et al.

Structure (london, England : 1993), 2023

Novel maternal duplication of 6p22.3-p25.3 with subtelomeric 6p25.3 deletion: new clinical findings and genotype-phenotype correlations.

Zhang L et al.

Molecular Cytogenetics, 2023

Point mutation L116R in interferon-regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells.

Staudenraus D et al.

European Journal of Immunology, 2022

The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4K59R mutation.

Sundararaj S et al.

Protein Science : a Publication of the Protein Society, 2022

IGH Translocations in Chinese Patients With Chronic Lymphocytic Leukemia: Clinicopathologic Characteristics and Genetic Profile.

Li Q et al.

Frontiers in Oncology, 2022

35720006 (PubMed )
Supplement: Table_2.xlsx › Sheet1

Circulating tumor DNA for comprehensive noninvasive monitoring of lymphoma treated with ibrutinib plus nivolumab.

Bruscaggin A et al.

Blood Advances, 2021

34500472 (PubMed )
Supplement: advancesADV2021004528-suppl2.xlsx › Table_S7

Structural determinants of the IRF4/DNA homodimeric complex.

Sundararaj S et al.

Nucleic Acids Research, 2021

An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.

Cherian MA et al.

The Journal of Biological Chemistry, 2018

Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia.

Nadeu F et al.

Leukemia, 2018

28924241 (PubMed )
Supplement: leu2017291x4.xlsx › Table_S7

Mutations driving CLL and their evolution in progression and relapse.

Landau DA et al.

Nature, 2015

26466571 (PubMed )
Supplement: NIHMS715090-supplement-Supplementary_Table_10.xlsx › CCF_DP_clustering

IRF4 mutations in chronic lymphocytic leukemia.

Havelange V et al.

Blood, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."