Varaico: Literature-Extracted Genetic Variants

Gene:IRF4
Variant:p.K123R
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IRF4

NM_002460.4:p.K123R

Associated Papers

Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus.

Xiao ZX et al.

Iscience, 2025

Genetic, epigenetic, and molecular determinants of multiple myeloma and precursor plasma cell disorders: a pathophysiological overview.

Sutanto H et al.

Medical Oncology (northwood, London, England), 2025

Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.

Wang G et al.

Structure (london, England : 1993), 2023

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

Sakthikumar S et al.

Veterinary and Comparative Oncology, 2023

37248814 (PubMed )
Supplement: supplement_1.xlsx › Supp._Table_5

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Ansari-Pour N et al.

Blood, 2023

36223594 (PubMed )
Supplement: BLOOD_BLD-2022-017010-mmc2.xlsx › Supplementary_Table_S2

NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial.

Rosa-Rosa JM et al.

Cancers, 2022

36291952 (PubMed )
Supplement: cancers-14-05169-s001.zip › cancers-1947661-supplementary › Supplementary_Tables.xlsx › Supplementary_Table_S3

Liquid Biopsy-Derived DNA Sources as Tools for Comprehensive Mutation Profiling in Multiple Myeloma: A Comparative Study.

Heestermans R et al.

Cancers, 2022

36230824 (PubMed )
Supplement: cancers-14-04901-s001.zip › cancers-1953828-supplementary.xlsx › Suppl_Table_S3

Circulating Tumor DNA: Less Invasive, More Representative Method to Unveil the Genomic Landscape of Newly Diagnosed Multiple Myeloma Than Bone Marrow Aspirates.

Liu Y et al.

Cancers, 2022

36230837 (PubMed )
Supplement: cancers-14-04914-s001.zip › cancers-1924136-supplementary.xlsx › Supplemental_Table_2

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities.

Giesen N et al.

Haematologica, 2022

35045690 (PubMed )
Supplement: 2021_279360_GIESEN_TABS5_SUPPL.xlsx › IMiD_resistance

The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4K59R mutation.

Sundararaj S et al.

Protein Science : a Publication of the Protein Society, 2022

Structural determinants of the IRF4/DNA homodimeric complex.

Sundararaj S et al.

Nucleic Acids Research, 2021

Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study.

Yasuda T et al.

Cancer Science, 2020

32619037 (PubMed )
Supplement: CAS-111-3367-s004.xlsx › Sup.Table4

DNA-Repair Gene Mutations Are Highly Prevalent in Circulating Tumour DNA from Multiple Myeloma Patients.

Mithraprabhu S et al.

Cancers, 2019

31261969 (PubMed )
Supplement: cancers-11-00917-s001.xlsx › TAS_results_n_36__31_RR__5_ND_

Germline Risk Contribution to Genomic Instability in Multiple Myeloma.

Janz S et al.

Frontiers in Genetics, 2019

Progress in the identification of gene mutations involved in multiple myeloma.

Hu Y et al.

Oncotargets and Therapy, 2019

Mutations In Thirty Hotspot Genes In Newly Diagnosed Chinese Multiple Myeloma Patients.

Hu Y et al.

Oncotargets and Therapy, 2019

Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.

Bolli N et al.

Leukemia, 2018

29789651 (PubMed )
Supplement: 41375_2018_37_MOESM14_ESM.xlsx › supp_Table1

An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.

Cherian MA et al.

The Journal of Biological Chemistry, 2018

Monitoring multiple myeloma by quantification of recurrent mutations in serum.

Rustad EH et al.

Haematologica, 2017

Mutational landscape reflects the biological continuum of plasma cell dyscrasias.

Rossi A et al.

Blood Cancer Journal, 2017

Genomic complexity of multiple myeloma and its clinical implications.

Manier S et al.

Nature Reviews. Clinical Oncology, 2017

Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients.

Kortuem KM et al.

Blood Cancer Journal, 2016

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.

Walker BA et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2015

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.

Lohr JG et al.

Cancer Cell, 2014

IRF4 mutations in chronic lymphocytic leukemia.

Havelange V et al.

Blood, 2011

Initial genome sequencing and analysis of multiple myeloma.

Chapman MA et al.

Nature, 2011

Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders in Thailand Population.

Jirabanditsakul C et al.

Technology in Cancer Research & Treatment, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."