Associated Papers
Genetic variants of the insulin receptor substrate-1 are influencing the therapeutic efficacy of oral antidiabetics.
Seeringer A et al.
Diabetes, Obesity & Metabolism, 2010
Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.
McGettrick AJ et al.
The Journal of Biological Chemistry, 2005
The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.
Wagner K et al.
Carcinogenesis, 2004
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Watanabe I et al.
Clinical Pharmacology and Therapeutics, 2003
Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling.
Yoshimura R et al.
Diabetes, 1997
Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.
Celi FS et al.
Diabetes/metabolism Research and Reviews, 0
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