Varaico: Literature-Extracted Genetic Variants

Gene:IRS1
Variant:p.A512P
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IRS1

NM_005544.3:p.A512P

Associated Papers

Translational and clinical comparison of whole genome and transcriptome to panel sequencing in precision oncology.

Kerle IA et al.

Npj Precision Oncology, 2025

39794422 (PubMed )
Supplement: 41698_2024_788_MOESM7_ESM.xlsx › patient_10_panel_small_variants

Significant variants of type 2 diabetes in the Arabian Region through an Integration of exome databases.

Goto K et al.

Plos One, 2021

Genetics and Genetic Testing in Pancreatic Cancer.

Whitcomb DC et al.

Gastroenterology, 2015

A rare co-segregation-mutation in the insulin receptor substrate 1 gene in one Chinese family with ankylosing spondylitis.

Rong J et al.

Plos One, 2015

Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.

Dong X et al.

Cancer Epidemiology, 2012

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

Dong X et al.

Gastroenterology, 2010

Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Turkish with type 2 diabetes mellitus.

Orkunoglu Suer FE et al.

Endocrine Journal, 2005

The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.

Wagner K et al.

Carcinogenesis, 2004

A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.

Watanabe I et al.

Clinical Pharmacology and Therapeutics, 2003

A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

Esposito DL et al.

The Journal of Clinical Endocrinology and Metabolism, 2003

Bioinformatic and experimental tools for identification of single-nucleotide polymorphisms in genes with a potential role for the development of the insulin resistance syndrome.

Bennet AM et al.

Journal of Internal Medicine, 2001

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.

Altshuler D et al.

Nature Genetics, 2000

Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.

Celi FS et al.

Diabetes/metabolism Research and Reviews, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."