Varaico: Literature-Extracted Genetic Variants

Gene:IRS1
Variant:p.R28C
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IRS1

NM_005544.3:p.R28C

Associated Papers

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function.

Greene MW et al.

Biochemical and Biophysical Research Communications, 2006

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.

Nawaratne R et al.

Molecular Endocrinology (baltimore, Md.), 2006

Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting.

Jacobs AR et al.

The Journal of Biological Chemistry, 2001

The insulin receptor substrate (IRS)-1 pleckstrin homology domain functions in downstream signaling.

Vainshtein I et al.

The Journal of Biological Chemistry, 2001

Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains.

Razzini G et al.

Molecular Endocrinology (baltimore, Md.), 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."