Associated Papers
C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality.
Fang J et al.
Journal of Thrombosis and Haemostasis : Jth, 2013
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.
Schaffner-Reckinger E et al.
Journal of Thrombosis and Haemostasis : Jth, 2009
CHO cells expressing the high affinity alpha(IIb)beta3 T562N integrin demonstrate enhanced adhesion under shear.
Legendre P et al.
Journal of Thrombosis and Haemostasis : Jth, 2006
Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3.
Nair S et al.
Thrombosis and Haemostasis, 2002
A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype.
Ruiz C et al.
Blood, 2001
A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3.
Kashiwagi H et al.
Blood, 1999
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