Associated Papers
Hemophagocytic Lymphohistiocytosis Gene Variants in Severe Aplastic Anemia and Their Impact on Hematopoietic Cell Transplantation Outcomes.
Rafati M et al.
Transplantation and Cellular Therapy, 2024
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.
Ogishi M et al.
The Journal of Experimental Medicine, 2023
NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis.
Bi X et al.
Journal of Hematology & Oncology, 2022
35902954 (PubMed )
Supplement: 13045_2022_1318_MOESM2_ESM.xlsx › Table_S6
Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes.
Zou H et al.
Nucleic Acids Research, 2022
35061901 (PubMed )
Supplement: gkac028_supplemental_files.zip › Table_S3_new.xlsx › Sheet1
Genetic characterization of pediatric primary hemophagocytic lymphohistiocytosis in China: a single-center study.
Zhang L et al.
Annals of Hematology, 2019
Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing.
Ono S et al.
International Journal of Hematology, 2018
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.
Linka RM et al.
Leukemia, 2012
A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.
Hirve N et al.
Plos One, 2012
The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.
Dierks C et al.
Cancer Research, 2010
20670954 (PubMed )
Supplement: 00085472can083719-sup-sfigs_1-16.pdf
The Tec family kinase Itk exists as a folded monomer in vivo.
Qi Q et al.
The Journal of Biological Chemistry, 2009
The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.
Rigby S et al.
The Journal of Biological Chemistry, 2009
Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.
Sacristán C et al.
European Journal of Immunology, 2009
Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.
Qi Q et al.
The Journal of Biological Chemistry, 2006
Inducible T cell tyrosine kinase (ITK): structural requirements and actin polymerization.
Tsoukas CD et al.
Advances in Experimental Medicine and Biology, 2006
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