Associated Papers
Population frequencies of thiopurine-related pharmacogenes in healthy individuals from Kosovo.
Pasha F et al.
Human Genome Variation, 2026
Inosine triphosphate pyrophosphatase activity as a potential predictor of methotrexate remission in juvenile idiopathic arthritis.
Forgiarini SS et al.
Arthritis & Rheumatology (hoboken, N.j.), 2026
Whole-Genome Sequencing Reveals a Novel GATA2 Mutation in Lower-Grade Glioma: Bioinformatics Analysis of Functional and Therapeutic Implications.
Handoko et al.
Cancers, 2025
The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.
Wang LY et al.
Innovation (cambridge (mass.)), 2025
Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review.
Hamdani S et al.
Frontiers in Genetics, 2025
Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn's disease patients.
Salazar J et al.
The Pharmacogenomics Journal, 2024
Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population.
Deva R et al.
Drug Metabolism and Personalized Therapy, 2024
An ITPA Enzyme with Improved Substrate Selectivity.
Burgis NE et al.
The Protein Journal, 2024
Impact of Mercaptopurine Metabolites on Disease Outcome in the AIEOP-BFM ALL 2009 Protocol for Acute Lymphoblastic Leukemia.
Franca R et al.
Clinical Pharmacology and Therapeutics, 2023
Associations of ITPA gene polymorphisms with outcomes among chronic hepatitis C patients treated with Peg-interferon/ribavirin: A 5-year follow-up study.
Liu Z et al.
Medicine, 2023
Role of Pharmacogenomics in the Efficacy and Safety of Thiopurines in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Gutiérrez-Valencia M et al.
Journal of Clinical Gastroenterology, 2023
Arginine-178 is an essential residue for ITPA function.
Burgis NE et al.
Archives of Biochemistry and Biophysics, 2023
Investigation of the Association Between ITPA Gene 94C>A Sequence Variant and Kidney Transplant Rejection in Iranian Kidney Transplant Recipients.
Heidari M et al.
Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation, 2023
Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease.
Suzuki S et al.
Bmc Gastroenterology, 2023
Genetic variants found in paediatric oncology patients with severe chemotherapy-induced toxicity: A case series.
Bernsen EC et al.
Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners, 2023
Pharmacogenetic Sex-Specific Effects of Methotrexate Response in Patients with Rheumatoid Arthritis.
Ceballos FC et al.
Pharmaceutics, 2023
ITPA Polymorphisms and the Incidence of Toxicities in Children with Acute Lymphoblastic Leukemia.
Svasdisant P et al.
Mediterranean Journal of Hematology and Infectious Diseases, 2023
Investigation of the Association Between the ITPA Gene 94C>A Gene Sequence Variant and Liver Transplant Rejection in Iranian Liver Transplant Recipients.
Heidari M et al.
Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation, 2022
Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia.
Sha HX et al.
Scientific Reports, 2022
Inosine Triphosphate Pyrophosphatase and NUDT15 are Good Predictors of Clinical Outcomes in Thiopurine-Treated Chinese Patients with Inflammatory Bowel Disease.
Luo X et al.
Therapeutic Drug Monitoring, 2022
ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia.
Fan POL et al.
Pediatric Hematology and Oncology, 2022
Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis.
Lee Y et al.
Pharmaceuticals (basel, Switzerland), 2022
Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis.
Barba E et al.
The Pharmacogenomics Journal, 2022
Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.
Zamzami MA
Cells, 2022
Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report.
Jeiziner C et al.
Pharmacogenomics and Personalized Medicine, 2022
Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising "MINT" sequencing strategy and therapeutic "DNA-TG" monitoring.
Guo HL et al.
Frontiers in Pharmacology, 2022
Immune-Related Gene Polymorphisms and Pharmacogenetic Studies in Nephrology.
Tziastoudi M et al.
Clinical Therapeutics, 2021
Multidisciplinary In-Depth Investigation in a Young Athlete Suffering from Syncope Caused by Myocardial Bridge.
Brancaccio M et al.
Diagnostics (basel, Switzerland), 2021
Association of Multiple Gene Polymorphisms Including Homozygous NUDT15 R139C With Thiopurine Intolerance During the Treatment of Acute Lymphoblastic Leukemia.
Kudo K et al.
Journal of Pediatric Hematology/oncology, 2021
Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.
Franca R et al.
Expert Opinion on Drug Metabolism & Toxicology, 2021
Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis.
Escudero-Contreras A et al.
Journal of Clinical Medicine, 2021
TPMT*3C as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia.
Jantararoungtong T et al.
Journal of Personalized Medicine, 2021
Polymorphism of genes involved in methotrexate pathway: Predictors of response to methotrexate therapy in Indian rheumatoid arthritis patients.
Singh A et al.
International Journal of Rheumatic Diseases, 2021
A Systematic Review and Meta-Analysis of Pharmacogenetic Studies in Patients with Chronic Kidney Disease.
Tziastoudi M et al.
International Journal of Molecular Sciences, 2021
Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.
Miao Q et al.
Scientific Reports, 2021
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.
Jena A et al.
Expert Review of Clinical Pharmacology, 2021
The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia.
Lee JM et al.
Children (basel, Switzerland), 2021
Structural dynamics of inosine triphosphate pyrophosphatase (ITPA) protein and two clinically relevant mutants: molecular dynamics simulations.
Houndonougbo Y et al.
Journal of Biomolecular Structure & Dynamics, 2021
Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.
Wang DS et al.
Pediatric Research, 2021
Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.
Aboul-Soud MAM et al.
Saudi Journal of Biological Sciences, 2021
Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study.
Chen ZY et al.
Frontiers in Pharmacology, 2021
ITPA:c.94C>A and NUDT15:c.415C>T Polymorphisms and Their Relation to Mercaptopurine-Related Myelotoxicity in Childhood Leukemia in Thailand.
Boonyawat B et al.
The Application of Clinical Genetics, 2021
NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy.
Pai AA et al.
Pharmacogenomics and Personalized Medicine, 2021
Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China.
Mao X et al.
Frontiers in Pediatrics, 2021
Association between inosine triphosphatase rs1127354 polymorphisms and ribavirin-induced anaemia and outcome in hepatitis C virus-infected patients: A meta-analysis.
Ma Z et al.
Journal of Clinical Pharmacy and Therapeutics, 2020