Varaico: Literature-Extracted Genetic Variants

Gene:ITPA
Variant:p.Q46Q
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ITPA

NM_033453.4:p.Q46Q

Associated Papers

ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia.

Fan POL et al.

Pediatric Hematology and Oncology, 2022

Classification and regression tree-based prediction of 6-mercaptopurine-induced leucopenia grades in children with acute lymphoblastic leukemia.

Naushad SM et al.

Cancer Chemotherapy and Pharmacology, 2019

Frequency of ITPA gene polymorphisms in Iranian patients with acute lymphoblastic leukemia and prediction of its myelosuppressive effects.

Azimi F et al.

Leukemia Research, 2015

Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in Chinese ALL children and possible association with mercaptopurine related toxicity.

Ma X et al.

International Journal of Clinical and Experimental Pathology, 2014

Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects.

Zamzami MA et al.

Journal of Hematology & Oncology, 2013

Effect of genetic polymorphisms on effectiveness of low-dose azathioprine in Japanese patients with systemic lupus erythematosus.

Nagamine A et al.

American Journal of Health-system Pharmacy : Ajhp : Official Journal of the American Society of Health-system Pharmacists, 2012

Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.

Dorababu P et al.

European Journal of Clinical Pharmacology, 2012

Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.

Kudo M et al.

Drug Metabolism and Pharmacokinetics, 2009

Clinical pharmacology and pharmacogenetics of thiopurines.

Sahasranaman S et al.

European Journal of Clinical Pharmacology, 2008

Pharmacogenomics in inflammatory bowel disease.

Egan LJ et al.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 2006

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.

Zelinkova Z et al.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 2006

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population.

Marinaki AM et al.

Nucleosides, Nucleotides & Nucleic Acids, 2004

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

Sumi S et al.

Human Genetics, 2002

ITPA polymorphisms do not predict additional risk beyond TPMT and NUDT15 for thiopurine-induced cytopenia in inflammatory bowel disease.

Jena A et al.

Revista De Gastroenterologia De Mexico (english), 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."