Varaico: Literature-Extracted Genetic Variants

Gene:JAK1
Variant:p.V658I
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JAK1

NM_002227.4:p.V658I

Associated Papers

Acute myeloid leukemia with bipotential erythroid and megakaryocytic differentiation: a case series and literature review.

Liu LW et al.

Journal of Hematopathology, 2025

Interaction between myelodysplasia-related gene mutations and ontogeny in acute myeloid leukemia.

McCarter JGW et al.

Blood Advances, 2023

37142255 (PubMed )
Supplement: BLOODA_ADV-2023-009675-mmc1.xlsx › supplemental_Table_2-Mutations

Clinical features and prognosis of pediatric acute lymphocytic leukemia with JAK-STAT pathway genetic abnormalities: a case series.

Hu M et al.

Annals of Hematology, 2023

Base editing screens map mutations affecting interferon-γ signaling in cancer.

Coelho MA et al.

Cancer Cell, 2023

36669486 (PubMed )
Supplement: mmc4.xlsx › BE_variants_-clinical_relevance

Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors-A Strategy for Hematological Malignancies?

Klein K et al.

Cancers, 2021

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation.

Lukes J et al.

Leukemia, 2020

Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors.

Park J et al.

Journal of Gastric Cancer, 2020

JAK/MAP kinase pathway activation and TP53 mutations in acute leukemia with megakaryocytic and erythroid differentiation.

Xiao W et al.

Leukemia, 2018

JAK1 somatic mutation in a myeloproliferative neoplasm.

Arulogun SO et al.

Haematologica, 2017

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.

Hornakova T et al.

Haematologica, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."