Varaico: Literature-Extracted Genetic Variants

Gene:JAK2
Variant:p.E543A
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JAK2

NM_004972.4:p.E543A

Associated Papers

Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.

Leroy E et al.

The Biochemical Journal, 2016

Amino acid residue E543 in JAK2 C618R is a potential therapeutic target for myeloproliferative disorders caused by JAK2 C618R mutation.

Wu QY et al.

Archives of Biochemistry and Biophysics, 2012

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.

Zhao L et al.

The Journal of Biological Chemistry, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."