Varaico: Literature-Extracted Genetic Variants

Gene:JAK2
Variant:p.R683K
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JAK2

NM_004972.4:p.R683K

Associated Papers

Nucleotide Substitution Biases in Related Cancer Driver Genes.

Khadre A et al.

International Journal of Molecular Sciences, 2025

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia.

Newman H et al.

Hemasphere, 2025

41306327 (PubMed )
Supplement: HEM3-9-e70269-s013.xlsx › Supplemental_Table_5_-_SSVs

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Varghese LN et al.

The Biochemical Journal, 2014

Disruption of E627 and R683 interaction is responsible for B-cell acute lymphoblastic leukemia caused by JAK2 R683G(S) mutations.

Wu QY et al.

Leukemia & Lymphoma, 2013

The effects of R683S (G) genetic mutations on the JAK2 activity, structure and stability.

Li F et al.

International Journal of Biological Macromolecules, 2013

Lymphoid malignancies: Another face to the Janus kinases.

Scott LM

Blood Reviews, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."