Varaico: Literature-Extracted Genetic Variants

Gene:JAK3
Variant:p.V674F
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JAK3

NM_000215.4:p.V674F

Associated Papers

Molecular pathology and computational profiling of Janus kinase 2 (JAK2) mutation in acute lymphoblastic leukemia: insights from a Pakistani cohort.

Maqsood S et al.

Laboratory Medicine, 2025

Janus Kinase Mutations in Mice Lacking PU.1 and Spi-B Drive B Cell Leukemia through Reactive Oxygen Species-Induced DNA Damage.

Lim M et al.

Molecular and Cellular Biology, 2020

JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.

Wahnschaffe L et al.

Cancers, 2019

31766351 (PubMed )
Supplement: cancers-11-01833-s001.zip › Supplementary_Table_3.xlsx › Tabelle1

PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.

Xiao W et al.

Blood Advances, 2018

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases.

Springuel L et al.

Cellular and Molecular Life Sciences : Cmls, 2016

JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.

Nairismägi ML et al.

Leukemia, 2016

26854024 (PubMed )
Supplement: leu201613x3.xls › ST8

Identification of a homozygous JAK3 V674A mutation caused by acquired uniparental disomy in a relapsed early T-cell precursor ALL patient.

Kawashima-Goto S et al.

International Journal of Hematology, 2015

Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.

Bergmann AK et al.

Genes, Chromosomes & Cancer, 2014

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