Varaico: Literature-Extracted Genetic Variants

Gene:JUN
Variant:p.S73A
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JUN

NM_002228.4:p.S73A

Associated Papers

Complementary modes of resistance to EGFR TKI in lung adenocarcinoma through MAPK activation and cellular plasticity.

Zatzman M et al.

Biorxiv : the Preprint Server for Biology, 2025

40654861 (PubMed )
Supplement: media-1.xlsx › Table_S2_-_IMPACT_Mutations

A micropeptide JunBP regulated by TGF-β promotes hepatocellular carcinoma metastasis.

Zhang H et al.

Oncogene, 2023

An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.

Waudby CA et al.

Nature Communications, 2022

Cooperative regulation of mouse aldose reductase (AKR1B3) gene transcription by Nrf2, TonEBP, and c-jun.

Nishinaka T et al.

Chemico-biological Interactions, 2019

Quantitative phosphoproteomic analysis reveals system-wide signaling pathways regulated by site-specific phosphorylation of Keratin-8 in skin squamous cell carcinoma derived cell line.

Tiwari R et al.

Proteomics, 2017

Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.

Gan XQ et al.

The Journal of Cell Biology, 2008

c-Jun promotes cellular survival by suppression of PTEN.

Hettinger K et al.

Cell Death and Differentiation, 2007

Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.

Oukka M et al.

The Journal of Experimental Medicine, 2004

Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains.

Weizman N et al.

The Journal of Biological Chemistry, 2003

c-Jun and p53 activity is modulated by SUMO-1 modification.

Muller S et al.

The Journal of Biological Chemistry, 2000

Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification.

Gjerset RA et al.

Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research, 1999

Role of the ATFa/JNK2 complex in Jun activation.

De Graeve F et al.

Oncogene, 1999

A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in nerve growth factor.

Rydén M et al.

The Journal of Biological Chemistry, 1997

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."