Varaico: Literature-Extracted Genetic Variants

Gene:KAT8
Variant:p.K274R
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KAT8

NM_032188.3:p.K274R

Associated Papers

Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.

Wang F et al.

Medcomm, 2025

WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.

Liu Y et al.

Oncogene, 2020

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

Zhang Y et al.

Nature Communications, 2019

TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function.

Zhong J et al.

Nucleic Acids Research, 2017

Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation.

McCullough CE et al.

The Journal of Biological Chemistry, 2016

Autoacetylation of the MYST lysine acetyltransferase MOF protein.

Yang C et al.

The Journal of Biological Chemistry, 2012

SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60.

Peng L et al.

Molecular and Cellular Biology, 2012

MYST protein acetyltransferase activity requires active site lysine autoacetylation.

Yuan H et al.

The Embo Journal, 2012

Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin.

Lu L et al.

Cell Research, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."