Associated Papers
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology.
Muhammad A et al.
Genome Medicine, 2024
38816749 (PubMed )
Supplement: 13073_2024_1340_MOESM3_ESM.xlsx › SpliceAI
A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes.
Chan M et al.
Elife, 2023
A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling.
Wu X et al.
Communications Biology, 2021
Recent molecular insights from mutated IKS channels in cardiac arrhythmia.
Dvir M et al.
Current Opinion in Pharmacology, 2014
Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2.
Wang Y et al.
The Journal of General Physiology, 2012
Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.
Chan PJ et al.
The Journal of General Physiology, 2012
Gating-related molecular motions in the extracellular domain of the IKs channel: implications for IKs channelopathy.
Wang YH et al.
The Journal of Membrane Biology, 2011
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