Associated Papers
Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Lau CHY et al.
Nature Communications, 2024
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.
Liu Z et al.
Bmc Biology, 2024
Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility.
Lamothe SM et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2018
Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
Thouta S et al.
Scientific Reports, 2018
Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.
Apaja PM et al.
Molecular Biology of the Cell, 2013
Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.
Durdagi S et al.
The Journal of Pharmacology and Experimental Therapeutics, 2012
Molecular determinants of pentamidine-induced hERG trafficking inhibition.
Dennis AT et al.
Molecular Pharmacology, 2012
Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.
Es-Salah-Lamoureux Z et al.
Biophysical Journal, 2011
Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.
Massaeli H et al.
Circulation Research, 2010
Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.
Wang L et al.
Molecular Pharmacology, 2009
Na+ permeation and block of hERG potassium channels.
Gang H et al.
The Journal of General Physiology, 2006
Molecular determinants of cocaine block of human ether-á-go-go-related gene potassium channels.
Guo J et al.
The Journal of Pharmacology and Experimental Therapeutics, 2006
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