Associated Papers
SPARC: a structural pathogenicity algorithm for risk classification of hERG variants.
Chatelain FC et al.
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 2026
Molecular determinants of HERG potassium channel blockade by domiphen bromide and benzethonium chloride.
Tang F et al.
Pflugers Archiv : European Journal of Physiology, 2025
Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome.
Zhao Z et al.
Ebiomedicine, 2024
Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.
Brewer KR et al.
Frontiers in Pharmacology, 2020
Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.
Helliwell MV et al.
The Journal of Biological Chemistry, 2018
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.
Zhang Y et al.
Biochemical Pharmacology, 2016
Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.
Melgari D et al.
Journal of Molecular and Cellular Cardiology, 2015
Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.
Du C et al.
Journal of Molecular and Cellular Cardiology, 2014
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV et al.
Genetic Testing and Molecular Biomarkers, 2013
Current pharmacogenomic studies on hERG potassium channels.
He FZ et al.
Trends in Molecular Medicine, 2013
Molecular determinants of hERG potassium channel inhibition by disopyramide.
El Harchi A et al.
Journal of Molecular and Cellular Cardiology, 2012
Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.
Ferrer T et al.
The Journal of Biological Chemistry, 2011
Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization.
Sintra Grilo L et al.
European Journal of Medicinal Chemistry, 2011
Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.
Massaeli H et al.
Circulation Research, 2010
Stereoselective Inhibition of the hERG1 Potassium Channel.
Grilo LS et al.
Frontiers in Pharmacology, 2010
Molecular determinants of hERG channel block by terfenadine and cisapride.
Kamiya K et al.
Journal of Pharmacological Sciences, 2008
Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).
Xu X et al.
Molecular Pharmacology, 2008
Drug block of the hERG potassium channel: insight from modeling.
Stansfeld PJ et al.
Proteins, 2007
Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.
Schwoerer AP et al.
Anesthesiology, 2007
Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine.
Siebrands CC et al.
Anesthesiology, 2007
Molecular determinants of HERG channel block.
Kamiya K et al.
Molecular Pharmacology, 2006
Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.
Stansfeld PJ et al.
Expert Opinion on Drug Metabolism & Toxicology, 2006
Block of HERG channels by berberine: mechanisms of voltage- and state-dependence probed with site-directed mutant channels.
Rodriguez-Menchaca A et al.
Journal of Cardiovascular Pharmacology, 2006
Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
Sánchez-Chapula JA et al.
Naunyn-schmiedeberg's Archives of Pharmacology, 2004
The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.
Witchel HJ et al.
Molecular Pharmacology, 2004
Structural determinants of HERG channel block by clofilium and ibutilide.
Perry M et al.
Molecular Pharmacology, 2004
Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.
Sănchez-Chapula JA et al.
Molecular Pharmacology, 2003
Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
Sánchez-Chapula JA et al.
The Journal of Biological Chemistry, 2002
HERG K+ channels: friend and foe.
Vandenberg JI et al.
Trends in Pharmacological Sciences, 2001
Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant.
Hosaka Y et al.
Channels (austin, Tex.), 0