Associated Papers
Molecular Determinants of Voltage-Dependent Gating in Kv11.1 Channels.
Hunter DV et al.
Advances in Experimental Medicine and Biology, 2026
Noncanonical pharmacological inhibition of the hERG K+ channel by a synthetic cannabinoid.
Cheng H et al.
Biochemical Pharmacology, 2025
Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels.
Chan AN et al.
Nature Communications, 2025
Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium Channels.
Chan AN et al.
Biorxiv : the Preprint Server for Biology, 2025
Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.
Zhang Y et al.
Cellular and Molecular Life Sciences : Cmls, 2024
Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Lau CHY et al.
Nature Communications, 2024
Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome.
Zhao Z et al.
Ebiomedicine, 2024
Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activation.
Codding SJ et al.
Biorxiv : the Preprint Server for Biology, 2024
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.
Helliwell MV et al.
Pharmaceuticals (basel, Switzerland), 2023
Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.
Sahoo N et al.
Scientific Reports, 2022
Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review.
El Harchi A et al.
Journal of Arrhythmia, 2022
Structural modeling of the hERG potassium channel and associated drug interactions.
Maly J et al.
Frontiers in Pharmacology, 2022
Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.
Baracaldo-Santamaría D et al.
International Journal of Molecular Sciences, 2021
Identification of a proton sensor that regulates conductance and open time of single hERG channels.
Wilson SL et al.
Scientific Reports, 2019
Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression.
Szendrey J et al.
Cardiovascular Research, 2019
The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Perissinotti L et al.
Molecular Pharmacology, 2019
The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure.
Codding SJ et al.
The Journal of General Physiology, 2019
Blockade of the Human Ether A-Go-Go-Related Gene (hERG) Potassium Channel by Fentanyl.
Tschirhart JN et al.
Molecular Pharmacology, 2019
The molecular determinants of R-roscovitine block of hERG channels.
Cernuda B et al.
Plos One, 2019
Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain.
de la Peña P et al.
Pflugers Archiv : European Journal of Physiology, 2018
Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.
Helliwell MV et al.
The Journal of Biological Chemistry, 2018
Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility.
Lamothe SM et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2018
Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
Thouta S et al.
Scientific Reports, 2018
Modulation of Kv 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator.
Sale H et al.
British Journal of Pharmacology, 2017
Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.
Wu W et al.
Cardiac Electrophysiology Clinics, 2016
Getting to the heart of hERG K(+) channel gating.
Perry MD et al.
The Journal of Physiology, 2015
The Link between Inactivation and High-Affinity Block of hERG1 Channels.
Wu W et al.
Molecular Pharmacology, 2015
Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.
Lörinczi É et al.
Nature Communications, 2015
Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.
Goodchild SJ et al.
Biophysical Journal, 2015
Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels.
Wu W et al.
The Journal of Physiology, 2014
Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.
Du C et al.
Journal of Molecular and Cellular Cardiology, 2014
Stoichiometry of altered hERG1 channel gating by small molecule activators.
Wu W et al.
The Journal of General Physiology, 2014
Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Thouta S et al.
Biophysical Journal, 2014
Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.
Dempsey CE et al.
Journal of Chemical Information and Modeling, 2014
Differential effects of the β-adrenoceptor blockers carvedilol and metoprolol on SQT1- and SQT2-mutant channels.
Bodi I et al.
Journal of Cardiovascular Electrophysiology, 2013
Current pharmacogenomic studies on hERG potassium channels.
He FZ et al.
Trends in Molecular Medicine, 2013
hERG K(+) channels: structure, function, and clinical significance.
Vandenberg JI et al.
Physiological Reviews, 2012
Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.
Van Slyke AC et al.
American Journal of Physiology. Cell Physiology, 2012
A molecular switch driving inactivation in the cardiac K+ channel HERG.
Köpfer DA et al.
Plos One, 2012
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.
El Harchi A et al.
Plos One, 2012
Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.
Garg V et al.
Molecular Pharmacology, 2011
Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules.
Zhou PZ et al.
Acta Pharmacologica Sinica, 2011
hERG potassium channel gating is mediated by N- and C-terminal region interactions.
Gustina AS et al.
The Journal of General Physiology, 2011
Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.
Grunnet M et al.
Molecular Pharmacology, 2011
In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channel.
Knape K et al.
Plos One, 2011