Varaico: Literature-Extracted Genetic Variants

Gene:KCNH2
Variant:p.W568L
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KCNH2

NM_000238.4:p.W568L

Associated Papers

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer.

Cross WCH et al.

Cancer Discovery, 2026

41563072 (PubMed )
Supplement: cd-24-0813_supplementary_table_7_suppst7.xlsx › C277

SPARC: a structural pathogenicity algorithm for risk classification of hERG variants.

Chatelain FC et al.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 2026

41443252 (PubMed )
Supplement: euaf327_supplementary_data.zip › Table-S1-V2.xlsx › All_missense_variants

A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1.

Alameh M et al.

Frontiers in Physiology, 2023

36860515 (PubMed )
Supplement: Table1.XLSX › missense_variants

Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels.

Bassetto CA et al.

Elife, 2021

Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels.

Wu W et al.

The Journal of Physiology, 2014

Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk.

Mann SA et al.

Journal of the American College of Cardiology, 2012

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.

Ferrer T et al.

The Journal of Biological Chemistry, 2011

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