Associated Papers
Noncanonical pharmacological inhibition of the hERG K+ channel by a synthetic cannabinoid.
Cheng H et al.
Biochemical Pharmacology, 2025
Harnessing AlphaFold to reveal hERG channel conformational state secrets.
Ngo K et al.
Biorxiv : the Preprint Server for Biology, 2025
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.
Helliwell MV et al.
Pharmaceuticals (basel, Switzerland), 2023
Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.
Al-Moubarak E et al.
Cellular and Molecular Life Sciences : Cmls, 2021
Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.
Baracaldo-Santamaría D et al.
International Journal of Molecular Sciences, 2021
Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.
Kudaibergenova M et al.
Frontiers in Pharmacology, 2020
Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.
Cheng H et al.
Journal of Molecular and Cellular Cardiology, 2019
The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Perissinotti L et al.
Molecular Pharmacology, 2019
Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.
Helliwell MV et al.
The Journal of Biological Chemistry, 2018
An in Vitro Assay of hERG K + Channel Potency for a New EGFR Inhibitor FHND004.
Jin T et al.
Frontiers in Pharmacology, 2018
Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.
Gardner A et al.
Molecular Pharmacology, 2017
New potential binding determinant for hERG channel inhibitors.
Saxena P et al.
Scientific Reports, 2016
Stoichiometry of altered hERG1 channel gating by small molecule activators.
Wu W et al.
The Journal of General Physiology, 2014
HERG1 channel agonists and cardiac arrhythmia.
Sanguinetti MC
Current Opinion in Pharmacology, 2014
ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.
Garg V et al.
Molecular Pharmacology, 2013
Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.
Garg V et al.
Molecular Pharmacology, 2011