Associated Papers
SPARC: a structural pathogenicity algorithm for risk classification of hERG variants.
Chatelain FC et al.
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 2026
Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels.
Chan AN et al.
Nature Communications, 2025
Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium Channels.
Chan AN et al.
Biorxiv : the Preprint Server for Biology, 2025
A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1.
Alameh M et al.
Frontiers in Physiology, 2023
Modeling long QT syndrome type 2 on-a-chip via in-depth assessment of isogenic gene-edited 3D cardiac tissues.
Veldhuizen J et al.
Science Advances, 2022
The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.
Kudaibergenova M et al.
Biophysical Journal, 2022
Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.
Brewer KR et al.
Frontiers in Pharmacology, 2020
Achieving high-sensitivity for clinical applications using augmented exome sequencing.
Patwardhan A et al.
Genome Medicine, 2015
Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.
Anderson CL et al.
Nature Communications, 2014
Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.
McBride CM et al.
The Journal of Membrane Biology, 2013
hERG K(+) channels: structure, function, and clinical significance.
Vandenberg JI et al.
Physiological Reviews, 2012
Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.
Subbotina J et al.
Proteins, 2010
Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation.
Choveau FS et al.
Biophysical Journal, 2009
Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.
Subbiah RN et al.
The Journal of Physiology, 2004
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2.
Splawski I et al.
Circulation, 2000