Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ11
Variant:p.K185E
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KCNJ11

NM_000525.4:p.K185E

Associated Papers

Sensitivity of KATP channels to cellular metabolic disorders and the underlying structural basis.

Li CG et al.

Acta Pharmacologica Sinica, 2016

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

Brereton MF et al.

Nature Communications, 2014

Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels.

Moran O et al.

Biophysical Chemistry, 2013

The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes.

Lang V et al.

Pharmacogenomics and Personalized Medicine, 2010

Modeling K(ATP) channel gating and its regulation.

Proks P et al.

Progress in Biophysics and Molecular Biology, 2009

Subunit-stoichiometric evidence for kir6.2 channel gating, ATP binding, and binding-gating coupling.

Wang R et al.

Molecular Pharmacology, 2007

Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2.

John SA et al.

The Journal of Physiology, 2003

Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures.

Wu J et al.

The Journal of Membrane Biology, 2002

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

Reimann F et al.

The Journal of Physiology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."