Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ11
Variant:p.N160D
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KCNJ11

NM_000525.4:p.N160D

Associated Papers

Inward rectifiers and their regulation by endogenous polyamines.

Baronas VA et al.

Frontiers in Physiology, 2014

Paradoxical activation of an inwardly rectifying potassium channel mutant by spermine: "(b)locking" open the bundle crossing gate.

Vilin YY et al.

Molecular Pharmacology, 2013

A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.

Bushman JD et al.

Plos One, 2013

Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.

Ponce-Balbuena D et al.

Molecular Pharmacology, 2012

Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism.

Bushman JD et al.

The Journal of Biological Chemistry, 2010

Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels.

Wheeler A et al.

Molecular Pharmacology, 2008

Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition.

Chan KW et al.

The Journal of General Physiology, 2008

Kir6.2 mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+ channels: implications in disease mechanism and sulfonylurea therapy.

Lin CW et al.

Diabetes, 2006

Long polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channels.

Xie LH et al.

The Journal of General Physiology, 2005

Differential nucleotide regulation of KATP channels by SUR1 and SUR2A.

Masia R et al.

Journal of Molecular and Cellular Cardiology, 2005

Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis.

Kurata HT et al.

The Journal of General Physiology, 2004

Concerted gating mechanism underlying KATP channel inhibition by ATP.

Drain P et al.

Biophysical Journal, 2004

Gating dependence of inner pore access in inward rectifier K(+) channels.

Phillips LR et al.

Neuron, 2003

ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites.

Markworth E et al.

Diabetes, 2000

Molecular biology of adenosine triphosphate-sensitive potassium channels.

Aguilar-Bryan L et al.

Endocrine Reviews, 1999

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

Trapp S et al.

The Journal of General Physiology, 1998

Octameric stoichiometry of the KATP channel complex.

Shyng S et al.

The Journal of General Physiology, 1997

Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit.

Shyng S et al.

The Journal of General Physiology, 1997

Association and stoichiometry of K(ATP) channel subunits.

Clement JP et al.

Neuron, 1997

Random assembly of SUR subunits in K(ATP) channel complexes.

Cheng WW et al.

Channels (austin, Tex.), 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."