Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ2
Variant:p.T141A
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KCNJ2

NM_000891.3:p.T141A

Associated Papers

Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis.

Reilly L et al.

Heart Rhythm, 2021

Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K⁺ (Kir2.1) channel.

Huang CW et al.

Pflugers Archiv : European Journal of Physiology, 2015

Driving force-dependent block by internal Ba(2+) on the Kir2.1 channel: Mechanistic insight into inward rectification.

Hsieh CP et al.

Biophysical Chemistry, 2015

Multiple residues in the p-region and m2 of murine kir 2.1 regulate blockage by external ba.

Lee YM et al.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2009

The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel.

Claydon TW et al.

The Journal of Biological Chemistry, 2003

The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.

Alagem N et al.

Biophysical Journal, 2003

Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.

Fujiwara Y et al.

The Journal of General Physiology, 2002

Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+.

Thompson GA et al.

The Journal of Physiology, 2000

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